What does this research mean for the field?

Severe pediatric diabetic ketoacidosis can rarely present with life-threatening multisystem complications, including dialysis-requiring acute kidney injury and cerebral microhemorrhages, necessitating continuous kidney replacement therapy when standard management fails. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe a rare, severe presentation of new-onset type 1 diabetes mellitus complicated by acute tubular injury, severe hypertension, and neurological involvement.

August 27, 2026Reports — Medical Cases Images and VideosOpen Access

Severe Pediatric Diabetic Ketoacidosis Complicated by Dialysis-Requiring Acute Tubular Injury, in a Child Newly Diagnosed with Type 1 Diabetes Mellitus: A Case Report

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Authors

AAAli AlamerSaad Specialist Hospital SASajjad AlkadhemSaad Specialist Hospital OKOsama KattihSaad Specialist Hospital

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Implication

Case report demonstrates severe diabetic ketoacidosis with dialysis-requiring acute tubular injury in a child, highlighting the need for vigilance when standard therapy fails.

Key Points

To describe a rare, severe presentation of new-onset type 1 diabetes mellitus complicated by acute tubular injury, severe hypertension, and neurological involvement.
Clinical and diagnostic evaluation of an 11-year-old female presenting with severe dehydration, altered consciousness, and refractory metabolic acidosis.
Diagnostic workup included continuous laboratory monitoring, brain magnetic resonance imaging, autoimmune testing, and a renal biopsy.
Initial laboratory results showed severe diabetic ketoacidosis with blood glucose of 684 mg/dL, pH < 7.0, HbA1c 12.2%, and anion gap > 37 mEq/L.
The patient developed oliguria, severe hypertension reaching 200 mmHg, cerebral microhemorrhages, and peak serum creatinine of 560 µmol/L by day 4.
Renal biopsy confirmed acute tubular injury associated with KDIGO stage 3 acute kidney injury, requiring continuous kidney replacement therapy.

Cite This Study

Alamer et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe99e10c91c1e92621642 https://doi.org/10.3390/reports9030283

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Implication

Case report demonstrates severe diabetic ketoacidosis with dialysis-requiring acute tubular injury in a child, highlighting the need for vigilance when standard therapy fails.

Severe Pediatric Diabetic Ketoacidosis Complicated by Dialysis-Requiring Acute Tubular Injury, in a Child Newly Diagnosed with Type 1 Diabetes Mellitus: A Case Report

Discussion

Member takes

Implication

Key Points

Cite This Study

Severe Pediatric Diabetic Ketoacidosis Complicated by Dialysis-Requiring Acute Tubular Injury, in a Child Newly Diagnosed with Type 1 Diabetes Mellitus: A Case Report

Discussion

Member takes

Implication

Key Points

Cite This Study

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