Why the study?
Does pindolol compared to propranolol differentially affect plasma catecholamines and blood pressure in patients with moderate essential hypertension?
Population
34 patients with moderate essential hypertension
Comparison
Pindolol for 8 weeks vs Propranolol for 8 weeks
Design
Cohort
Follow-up
8 weeks of treatment and 1 week post-treatment
Authors
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Pindolol's broader catecholamine reduction versus propranolol should not yet change practice; leaves open need for outcome trials in essential hypertension.
Does pindolol compared to propranolol differentially affect plasma catecholamines and blood pressure in patients with moderate essential hypertension?
Beta-blockers with and without intrinsic sympathomimetic activity have different effects on plasma catecholamine levels despite similar blood pressure reductions.
Kirsten et al. (1982) studied this question.
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