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November 1, 1967Proceedings of the National Academy of SciencesOpen Access

Rescue of the defective murine sarcoma virus genome by radiation-induced leukemia virus from C57BL mice.

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Population

C57BL mice

Design

Preclinical

Authors

HIHoward J. IgelBoston Children's Hospital RHRobert J. HuebnerThe University of Texas at Austin BDB Deppa

Discussion

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Implication

Preclinical findings in animal models require human validation; leaves open translation to clinical practice.

Structured PICO

P

Population

C57BL mice

I

Intervention

Radiation-induced leukemia virus

O

Outcome

Rescue of the defective murine sarcoma virus genome

Cite This Study

Igel et al. (1967) studied this question.

synapsesocial.com/papers/6a8ff87eaa54517f3533c438 https://doi.org/10.1073/pnas.58.5.1870

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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1Biological Studies on the Rous Sarcoma Virus. V. Preparation of Improved Standard Lots of the Virus for Use in Quantitative Investigations1956 · 65 citations
2Leukemogenic Activity of Filtrates from Radiation-Induced Lymphoid Tumors of Mice1959 · 365 citations
3Experiment and Discussion on Leukaemogenesis by Cell-free Extracts of Radiation-induced Leukaemia in Mice1962 · 123 citations