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August 27, 2026Acta cardiologica. Supplementum

The long journey of TAVR: from procedural feasibility to integrated clinical and biomechanical predictors of complications

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Authors

TVTommaso VivaPLPatrizio Lancellotti

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Overview

Review demonstrates the transition from feasibility to integrated biomechanical risk prediction in transcatheter aortic valve replacement, highlighting avenues to minimize procedural complications.

Key Points

  • To review the historical evolution of transcatheter aortic valve replacement (TAVR) and assess how integrated clinical and biomechanical models improve the prediction of procedural complications.
  • Narrative review of technological advancements and clinical trial milestones in transcatheter aortic valve replacement.
  • Evaluation of biomechanical modeling, patient-specific anatomical imaging, and computational simulations used for pre-procedural risk stratification.
  • TAVR has expanded from high-risk, salvage applications to an established standard of care across broader patient risk categories.
  • Integration of biomechanical simulations with standard clinical variables improves prediction of adverse outcomes such as paravalvular regurgitation, annular rupture, and conduction disturbances.

Cite This Study

Viva et al. (2026) studied this question.

synapsesocial.com/papers/6a9005f810c91c1e926226c2https://doi.org/10.1080/00015385.2026.2721692
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