Why the study?
Do vascular risk factors and baseline clinical variables predict mortality, dementia, or poor clinical course in patients with late-onset depression?
Population
85 participants, comprising 50 patients with late-onset depression (LOD) and 35 healthy age-matched controls.
Design
Cohort
Follow-up
3 years
Authors
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Late-onset depression may elevate mortality and dementia risk; leaves open whether vascular/inflammatory markers predict outcomes, needing prospective validation.
Do vascular risk factors and baseline clinical variables predict mortality, dementia, or poor clinical course in patients with late-onset depression?
Late-onset depression is associated with high mortality and dementia risk, with poor outcomes predicted by vascular and inflammatory markers such as lower HDL and raised ESR.
Baldwin et al. (2005) studied this question.
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