Key result
The combination of serum NT-proBNP and D-dimer levels independently predicted the occurrence of no-reflow phenomenon after emergency PCI in patients with acute coronary syndrome (AUC 0.909).
Why the study?
To investigate the value of NT-proBNP and D-dimer in predicting the occurrence of no reflow in ACS patients undergoing emergency PCI.
Do serum NT-proBNP and D-dimer levels predict the occurrence of no-reflow phenomenon in ACS patients undergoing emergency PCI?
Observational (n=168)
Do serum NT-proBNP and D-dimer levels predict the occurrence of no-reflow phenomenon in ACS patients undergoing emergency PCI?
The combination of NT-proBNP and D-dimer serves as a strong independent predictor of the no-reflow phenomenon in ACS patients undergoing emergency PCI.
May aid no-reflow risk stratification in ACS; leaves open prospective validation before clinical adoption.
Acute coronary syndrome (ACS) is a critical illness in cardiovascular disease. The purpose of this study was to investigate the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and D-dimer in predicting the occurrence of no reflow in emergency percutaneous coronary intervention (PCI) in patients with ACS. One hundred and sixty-eight ACS patients were recruited, including 88 patients with normal reflow and 80 patients with no reflow after emergency PCI. The levels of serum NT-proBNP and D-dimer in the patients were detected before PCI, immediately after PCI, 2 hours, and 6 months after PCI. The ROC curve was used to evaluate the predictive value of NT-proBNP and D-dimer in no-reflow phenomenon. Logistic regression model was used to analyze the independent influencing factors of no reflow phenomenon. Logistic regression analysis confirmed that NT-proBNP and D-dimer were independent predictors of the occurrence of no reflow in the total population. The ROC curve showed that the AUC value was 0.909 when NT-proBNP combined with D-dimer. The detection of NT-proBNP combined with D-dimer was helpful to predict the occurrence of no-reflow phenomenon after emergency PCI in ACS patients.
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Diao et al. (2021) conducted an observational in Acute coronary syndrome (ACS) (n=168). Serum NT-proBNP and D-dimer levels was evaluated on Occurrence of no-reflow phenomenon after emergency PCI (AUC 0.909). The combination of serum NT-proBNP and D-dimer levels independently predicted the occurrence of no-reflow phenomenon after emergency PCI in patients with acute coronary syndrome (AUC 0.909).
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