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July 16, 2010Journal of Clinical HypertensionOpen Access

Evaluation of N‐Terminal Prohormone B‐Type Natriuretic Peptide in Patients With Acute Coronary Syndromes and Percutaneous Coronary Intervention

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Key result

NT-proBNP levels were significantly increased before and after PCI and up to 3 months in patients with ACS compared to those without ACS, demonstrating slow kinetics.

Why the study?

What are the kinetics of NT-proBNP compared to other cardiac biomarkers in patients with acute coronary syndrome undergoing percutaneous coronary intervention?

Population

300 consecutive patients with acute coronary syndrome undergoing successful reperfusion with percutaneous…

Comparison

Serial measurement of NT-proBNP and other… vs 300 patients without ACS

Design

Cohort

Follow-up

24 months

Authors

ΚΛΚωνσταντίνος ΛαμπρόπουλοςEvangelismos HospitalAMAndreas MarinakisHellenic Air ForceDSDimitrios P. SokolisAcademy of Athens

Discussion

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Implication

May warrant caution in serial NT-proBNP interpretation up to 3 months post-PCI in ACS; leaves open its incremental prognostic utility.

Study Design

Type

Observational (n=600)

Structured PICO

What are the kinetics of NT-proBNP compared to other cardiac biomarkers in patients with acute coronary syndrome undergoing percutaneous coronary intervention?

P
Population
600 patients (300 with acute coronary syndrome undergoing successful PCI and 300 without ACS) followed for up to 24 months to assess biomarker kinetics.
E
Exposure
Serial measurement of NT-proBNP and other biomarkers before PCI, 2 days after, and at 1, 3, 6, 12, 18, and 24 months
C
Comparator
300 patients without ACS
O
Outcome
NT-proBNP levels over timesurrogate

NT-proBNP exhibits slow normalization kinetics up to 3 months post-PCI in ACS patients, unlike other cardiac biomarkers, suggesting prolonged neurohormonal activation especially in high-risk individuals.

Cite This Study

Λαμπρόπουλος et al. (2010) conducted an observational in Acute coronary syndrome (n=600). Acute coronary syndrome and percutaneous coronary intervention vs. Patients without acute coronary syndrome was evaluated on N-terminal prohormone B-type natriuretic peptide (NT-proBNP) levels over time. NT-proBNP levels were significantly increased before and after PCI and up to 3 months in patients with ACS compared to those without ACS, demonstrating slow kinetics.

synapsesocial.com/papers/6a22ddf6e316c81622c46b24https://doi.org/10.1111/j.1751-7176.2010.00354.x
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Also Consider

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