Key result
STEMI patients undergoing primary PCI see elevated NT-proBNP rates rise to ~21% on day one.
Why the study?
Do serum NT-proBNP levels increase dynamically and correlate with left ventricular dysfunction in patients with STEMI treated with primary PCI?
Observational (n=53)
No
Do serum NT-proBNP levels increase dynamically and correlate with left ventricular dysfunction in patients with STEMI treated with primary PCI?
Serum NT-proBNP levels increase significantly 24-48 hours after STEMI onset and correlate with reduced left ventricular ejection fraction (<50%).
May support serial NT-proBNP assessment post-STEMI; leaves open validation for LV dysfunction risk stratification.
In the recent years important biomarkers have emerged as tools for diagnosis and risk stratification in cardiovascular diseases. Such markers are B- type natriuretic peptide ( BNP) and N- terminal B- type natriuretic peptide (NT-proBNP). Peripheral blood for the serum levels of NT-proBNP was taken from patients with STEMI before PCI and 24-48hours after the onset of the symptoms of myocardial infarction. Three of the samples from all 53 turned out to be positive to NT - proBNP concentration on Day 0. On day 1 there was a significant elevation of the positive samples 11 from 53 patients ( 20,7%) ( p = 0,01). All patients with STEMI and elevated serum levels of NT- proBNP have left ventricular ejection fraction <50%. Our results imply that NT -proBNP level and its increase in the serum may be used as a biomarker for the severity of the ischemic heart disease.
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Kashlov et al. (2016) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=53). Percutaneous coronary intervention (PCI) vs. Baseline (Day 0) was evaluated on Positive NT-proBNP concentration on Day 1 (p=0.01). In patients with STEMI treated with primary PCI, the proportion of patients with elevated NT-proBNP significantly increased to 20.7% on Day 1 compared to baseline (p=0.01).
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