Key result
NT-proBNP values were significantly higher in patients with acute myocardial infarction compared to healthy volunteers (943 vs. 162.5 pg/ml, p=0.0001), and in NSTEMI compared to STEMI patients.
Why the study?
Recent investigations implicate NT-proBNP in different cardiac and non-cardiac diseases and suggest different release mechanisms in patients with STEMI and NSTEMI.
Does NT-proBNP level correlate with infarct type, location, and culprit lesion in patients with acute myocardial infarction without heart failure?
Cross-Sectional (n=66)
No
Does NT-proBNP level correlate with infarct type, location, and culprit lesion in patients with acute myocardial infarction without heart failure?
Absolute Event Rate: 943% vs 162.5%
p-value: p=0.0001
NT-proBNP levels are elevated in AMI patients without heart failure and are significantly higher in NSTEMI, anterior infarctions, and left coronary artery lesions, suggesting its release is driven by the extent of ischemic tissue.
NT-proBNP was associated with infarct type and location in AMI without HF; hypothesis-generating for ischemic burden but requires prospective validation.
NT-proBNP is marker of acute heart failure. Recent investigation implicate its role in different cardiac and non-cardiac diseases and different mechanism of release in patients with STEMI and NSTEMI. Our study included 66 patients with diagnosis of acute myocardial infarction, hospitalized in Clinical Centre Kragujevac. We evaluated standard biochemical analysis including NTproBNP, electrocardiography, transthoracic echocardiography and coronary angiography. The most common cardiovascular risk factors were emotional stress (93,94%), and physical inactivity( 81,82%). NT-proBNP values were higher in patients with AMI vs health volunteers (943 vs. 162,5 pg/ml, p = 0,0001), NSTEMI vs STEMI patients (1427 pg/ml vs. 592 pg/m, p = 0,005), patients with culprit lesion on left vs right coronary artery (1421 vs. 548, p =0.02), and anterior vs inferior location AMI (1714vs. 625, p =0.022). We found positive correlation NT-proBNP values with CRP, urea, creatinine, and negative correlation with triglicerides, hemoglobin, left ventricular ejection fraction. Higher values of NT-proBNP values are recorded in patients with AMI, NSTEMI, anterior location AMI and with culprit lesion on left coronary artery.
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Vlajovic et al. (2023) conducted a cross-sectional in Acute myocardial infarction without heart failure (n=66). Acute myocardial infarction vs. Healthy volunteers was evaluated on NT-proBNP levels (pg/ml) (p=0.0001). NT-proBNP values were significantly higher in patients with acute myocardial infarction compared to healthy volunteers (943 vs. 162.5 pg/ml, p=0.0001), and in NSTEMI compared to STEMI patients.
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