Key result
Uncontrolled type 2 diabetes was associated with a highly significant increase in the Apo B100/Apo A1 ratio compared to controlled diabetes and non-diabetic controls.
Why the study?
Is the Apo B100/Apo A1 ratio elevated in uncontrolled type 2 diabetic patients compared to controlled diabetics and healthy controls?
Observational (n=60)
Is the Apo B100/Apo A1 ratio elevated in uncontrolled type 2 diabetic patients compared to controlled diabetics and healthy controls?
Prolonged hyperglycemia in type 2 diabetes is associated with dyslipidemia, and the Apo B100/Apo A1 ratio may serve as a useful predictive parameter for CAD risk.
Apo B100/Apo A1 ratio may mark CAD risk in uncontrolled T2DM; hypothesis-generating and requires prospective validation before clinical use.
Background: this study was undertaken to study the biochemical effects of lipoproteins and apolipoproteins on uncontrolled Egyptian patients with type 2 diabetes mellitus, and to study if Apo B100/Apo A1 ratio can be used as a predictive factor for assessment of CAD risk in this patients. Patients & Methods: this study was carried out on a group of 60 patients; 20 were non diabetic controls and 40 diabetic patients, who were subdivided into : controlled type 2 diabetic patients (Group I) and uncontrolled type 2 diabetic patients (Group II), based on their glycated hemoglobin level. Levels of triacylglycerols or triglycerides (TG), total cholesterol (TC), HDL-C, Apolipoprotein A1 and Apolipoprotein B100, in addition to fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) were estimated,and also, levels of LDL-C were calculated by Friedewald’s formula in all studied cases. Blood samples were collected after an overnight fasting of 10-12 hours, and divided into two parts, the 1st for separation of serum and the 2nd collected in an EDTA-containing tube for HbA1c determination. Results: the obtained results revealed that, levels of total cholesterol, LDL-C and Apo B100 were comparable with no statistical significance between uncontrolled type 2 diadetic patients (group II) with controlled type 2 diabetic patients (group I) and control group.While, a highly significant increase in triacylglycerols levels in group II compared to group I and control group. In contrast, a highly significant decrease in HDL-C and Apo A1 levels in group II compared to group I and control group. Highly significant increase in Apo B100/Apo A1 ratio in group II compared to group I, and a significant increase compared to control group, while it was comparable with no statistical significance in group I compared to control group. Conclusion: this study showed that there was an adverse effect of prolonged hyperglycemia on the apolipoproteins in diabetic patients which is associated with dyslipidemia, good glycemic control is able to make an improvement on this dyslipidemia. Apo B100/Apo A1 ratio can be used as a predictive parameter for assessment of CAD risk in type 2 diabetes mellitus.
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Aboelela et al. (2014) conducted an observational in Type 2 diabetes mellitus (n=60). Uncontrolled type 2 diabetes vs. Controlled type 2 diabetes and non-diabetic controls was evaluated on Apo B100/Apo A1 ratio. Uncontrolled type 2 diabetes was associated with a highly significant increase in the Apo B100/Apo A1 ratio compared to controlled diabetes and non-diabetic controls.
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