April 21, 2010EndocrinologyOpen Access

Chromogranin A and the Autonomic System: Decomposition of Heart Rate Variability and Rescue by Its Catestatin Fragment

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Why the study?

Does Catestatin replacement improve heart rate variability in Chromogranin A knockout mice?

Population

Wild-type (WT) and Chromogranin A (Chga) knockout (KO) mice

Comparison

Catestatin (CST) (human CHGA(352-372)) replacement vs Wild-type mice and baseline measurements before…

Design

Preclinical

Authors

NDNagendu B. Dev JGJiaur R. GayenCentral Drug Research Institute DODaniel T. O’ConnorNova Southeastern University

Discussion

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Implication

Catestatin may restore HRV in Chga KO mice; leaves open translation to human autonomic or cardiovascular disorders.

Structured PICO

Does Catestatin replacement improve heart rate variability in Chromogranin A knockout mice?

Population

Wild-type (WT) and Chromogranin A (Chga) knockout (KO) mice

Intervention

Catestatin (CST) (human CHGA(352-372)) replacement

Comparator

Wild-type mice and baseline measurements before CST replacement

Outcome

Heart rate variability (HRV) evaluated by beat-to-beat measurements, time and frequency domains, and Lorenz nonlinear return analysessurrogate

Catestatin replacement restores diminished heart rate variability and autonomic tone in Chromogranin A knockout mice, suggesting a potential therapeutic target for cardiovascular disorders with adverse HRV profiles.

Cite This Study

Dev et al. (2010) studied this question.

synapsesocial.com/papers/6a901233e16d749e8fc9106b https://doi.org/10.1210/en.2009-1110

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Chromogranin A and the Autonomic System: Decomposition of Heart Rate Variability and Rescue by Its Catestatin Fragment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Chromogranin A and the Autonomic System: Decomposition of Heart Rate Variability and Rescue by Its Catestatin Fragment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider