Cardiac Failure Simulating Viral Hepatitis

Case Reports1 May 1962Cardiac Failure Simulating Viral HepatitisThree Cases with Serum Transaminase Levels above 1,000ROBERT G. LOGAN, M.D., FRANK M. MOWRY, M.D., RICHARD D. JUDGE, M.D.ROBERT G. LOGAN, M.D., FRANK M. MOWRY, M.D., RICHARD D. JUDGE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-5-784 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCardiac failure is a recognized cause of hepatic dysfunction. Three cases of congestive failure due primarily to aortic stenosis have recently come to our attention, each of which manifested striking clinical and laboratory evidence of hepatic necrosis. The serum levels of glutamic-oxalacetic transaminase in each instance exceeded 1,000 units. In two of these cases a clinical diagnosis of viral hepatitis was made antemortem, but autopsy in all three showed only centrilobular necrosis of the liver.CASE REPORTSCASE 1A 27-year-old white male was admitted to the University of Michigan Medical Center for the third time on February 2, 1961....References1. KARMENWRÓBLEWSKILADUE AFJS: Transaminase activity in human blood. J. Clin. Invest. 34: 126, 1955. CrossrefMedlineGoogle Scholar2. AGRESSKIM CMJH: Evaluation of enzymatic testing in the diagnosis of heart disease. Amer. J. Cardiol. 6: 641, 1960. CrossrefMedlineGoogle Scholar3. AGRESS CM: Evaluation of the transaminase test. Amer. J. Cardiol. 3: 74, 1959. CrossrefMedlineGoogle Scholar4. WRÓBLEWSKI F: The clinical significance of alterations in transaminase activities of serum and other body fluids. Advance Clin. Chem. 1: 313, 1958. CrossrefMedlineGoogle Scholar5. WRÓBLEWSKI F: The clinical significance of transaminase activities of serum. Amer. J. Med. 27: 911, 1959. 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RICHMANDELMANGROB SMAJD: Alterations in indices of liver function in congestive heart failure with particular reference to serum enzymes. Amer. J. Med. 30: 211, 1961. CrossrefMedlineGoogle Scholar12. ZELMANWANGAPPELHANZ SCCI: Transaminase in serum and liver correlated with liver cell necrosis in needle aspiration biopsies. Amer. J. Med. Sci. 237: 323, 1959. CrossrefMedlineGoogle Scholar13. BANGIVERSONJAGTTOBIASSEN NJKTG: Serum glutamic-oxaloacetic transaminase activity as an index of centrilobular liver cell necrosis. Amer. J. Med. 11: 170, 1951. MedlineGoogle Scholar14. ELLENBERGOSSERMAN MKE: The role of shock in the production of central liver cell necrosis. Amer. J. Med. 11: 170, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT G. LOGAN, M.D.; FRANK M. MOWRY, M.D.; RICHARD D. JUDGE, M.D.Affiliations: Ann Arbor, MichiganFrom the Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.Requests for reprints should be addressed to Dr. Robert G. Logan, M.D., Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan. 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MUSA, M.D.Centrilobular Hepatic Necrosis in Cardiac Failure 1 May 1962Volume 56, Issue 5_Part_1Page: 784-788KeywordsAminotransferasesHeart failureHepatitis AHepatitis E virusHypotensionLesionsLiverNecrosisResearch laboratoriesStenosis ePublished: 1 December 2008 Issue Published: 1 May 1962 PDF downloadLoading ...