Why the study?
Does aspirin, dipyridamole, or cod liver oil improve graft patency and reduce intimal hyperplasia in a canine hypercholesterolemic veno-arterial allograft model?
Population
Canine, hypercholesterolemic veno-arterial allograft model (n=144 grafts)
Comparison
Aspirin, dipyridamole, combined aspirin and… vs Control
Design
Preclinical
Follow-up
90 days
Authors
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These agents showed no patency benefit in this canine model; leaves open any role in human vascular grafts.
Does aspirin, dipyridamole, or cod liver oil improve graft patency and reduce intimal hyperplasia in a canine hypercholesterolemic veno-arterial allograft model?
Aspirin, dipyridamole, and cod liver oil failed to improve graft patency or reduce intimal hyperplasia in a canine model of accelerated arteriosclerosis.
DeCampli et al. (1988) studied this question.
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