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March 1, 1982Anaesthesia

Laparoscopy — a stressful procedure

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Why the study?

Does fentanyl compared to Althesin infusion alter the metabolic and hormonal response in patients undergoing laparoscopy?

Population

22 patients undergoing laparoscopy

Comparison

Nitrous oxide-oxygen anaesthesia supplemented… vs Nitrous oxide-oxygen anaesthesia supplemented…

Design

Cohort

Follow-up

1 hour postoperatively

Authors

GCGriselda CooperASA. M. SCOGGINSIWI.D. Ward

Discussion

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Overview

No difference in stress response with fentanyl versus Althesin during laparoscopy; leaves open optimal technique selection pending randomized trials.

Structured PICO

Does fentanyl compared to Althesin infusion alter the metabolic and hormonal response in patients undergoing laparoscopy?

P
Population
22 patients undergoing laparoscopy
I
Intervention
Nitrous oxide-oxygen anaesthesia supplemented with 150 micrograms fentanyl
C
Comparator
Nitrous oxide-oxygen anaesthesia supplemented with an Althesin infusion
O
Outcome
Metabolic and hormonal response (plasma cortisol, prolactin, and blood glucose concentrations)surrogate

Laparoscopy induces a significant stress response characterized by elevated cortisol, prolactin, and glucose, which is not differentially affected by fentanyl versus Althesin supplementation.

Cite This Study

Cooper et al. (1982) studied this question.

synapsesocial.com/papers/6a901a4bebb21526730d3339https://doi.org/10.1111/j.1365-2044.1982.tb01096.x
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