Why the study?
Does a glucose-containing pump prime during extracorporeal circulation affect plasma potassium levels in relation to insulin activity in patients undergoing open-heart surgery?
Does a glucose-containing pump prime during extracorporeal circulation affect plasma potassium levels in relation to insulin activity in patients undergoing open-heart surgery?
Changes in plasma potassium during extracorporeal circulation with a glucose-containing prime do not appear to be driven by insulin activity.
Do not attribute early potassium declines to insulin with glucose prime; leaves open non-insulin mechanisms in cardiac surgery.
In order to investigate the possible relationship between a glucose-containing pump prime and changes in plasma potassium during extracorporeal circulation, determinations were made of blood glucose and plasma insulin, potassium, and magnesium in 18 subjects undergoing open-heart surgery. In 6 of the patients, the same parameters had been measured during a pre-operative glucose tolerance test. It was found that the elimination of glucose was considerably impaired during extracorporeal circulation, in spite of high insulin levels. During the first minutes of extracorporeal circulation, plasma potassium fell more than during the glucose tolerance test, in spite of comparable insulin levels. It is concluded that changes in plasma potassium during extracorporeal circulation do not reflect insulin activity to any noticeable extent.
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Valentin et al. (1975) studied this question.
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