Key result
Vasopressin infusion successfully restored blood pressure and allowed continuation of transfusion in a patient with a severe, catecholamine-unresponsive hypotensive transfusion reaction.
Why the study?
Does vasopressin infusion improve blood pressure in a patient with an ACE inhibitor-associated hypotensive transfusion reaction unresponsive to catecholamines?
Case Report (n=1)
Does vasopressin infusion improve blood pressure in a patient with an ACE inhibitor-associated hypotensive transfusion reaction unresponsive to catecholamines?
Vasopressin may be an effective rescue therapy for severe hypotensive transfusion reactions in patients on ACE inhibitors who are unresponsive to catecholamines.
May support vasopressin consideration in refractory hypotensive transfusion reactions; leaves open confirmation in prospective studies.
Hypotensive transfusion reactions, which account for almost 3% of all transfusion reactions, are associated with patients treated with angiotensin-converting enzyme inhibitors. The current hypothesis suggests that they are caused by bradykinin-induced vasodilation in the absence of allergic, hemolytic, or septic mechanisms. The hypotension observed frequently is unresponsive to conventional therapy with catecholamines. The suggested intraoperative management includes cessation of transfusion and washing red blood cells before blood replacement. We present a patient experiencing a severe intraoperative hypotensive transfusion reaction, unresponsive to epinephrine and norepinephrine, in whom we were able to restore blood pressure and continue the transfusion of blood and plasma by infusing vasopressin.
No takes yet. Share an insight, caveat, or question.
Pollard et al. (2017) conducted a case report in Hypotensive transfusion reaction (n=1). Vasopressin was evaluated on Restoration of blood pressure and continuation of transfusion. Vasopressin infusion successfully restored blood pressure and allowed continuation of transfusion in a patient with a severe, catecholamine-unresponsive hypotensive transfusion reaction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: