September 1, 1999Brain ResearchOpen Access

Acetylcholine release from cat carotid bodies

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Population

Carotid bodies removed from anesthetized cats (n=12 experiments)

Comparison

Incubation in physiological salt solution… vs Incubation under normoxic/normocapnic conditions

Design

Preclinical

Follow-up

30 minutes

Authors

RFRobert S. FitzgeraldJohns Hopkins University MSMachiko ShirahataJohns Hopkins University HWHay-Yan WangNational Sun Yat-sen University

Discussion

Member takes

Implication

Supports ACh as carotid body chemotransmitter in hypoxia; leaves open human chemoreflex relevance.

Structured PICO

Population

Carotid bodies removed from anesthetized cats (n=12 experiments)

Intervention

Incubation in physiological salt solution bubbled with stimulating conditions (hypoxia/hypercapnia: 4% O2/2% CO2, 0% O2/5% CO2, or 4% O2/10% CO2) for 30 minutes

Comparator

Incubation under normoxic/normocapnic conditions (21% O2/6% CO2)

Outcome

Acetylcholine (ACh) content released into the incubation medium, measured by high performance liquid chromatography-electrochemical detectionsurrogate

Hypoxia and hypercapnia significantly increase acetylcholine release from cat carotid bodies, supporting its role as a stimulating transmitter in chemosensory responses.

Cite This Study

Fitzgerald et al. (1999) studied this question.

synapsesocial.com/papers/6a901cdd4e236145812b03a8 https://doi.org/10.1016/s0006-8993(99)01777-1

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Acetylcholine release from cat carotid bodies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acetylcholine release from cat carotid bodies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider