Key result
Acetylcholine fulfills all eight criteria as an essential excitatory synaptic transmitter in carotid body chemotransduction.
Population
Carotid body chemotransduction models (basic science review)
Design
Review
Authors
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Bolsters carotid body physiology; leaves open therapeutic targeting of cholinergic transmission in hypoxia-related disorders.
This review supports the cholinergic hypothesis, confirming that acetylcholine acts as an essential excitatory transmitter in carotid body oxygen sensing.
Robert S. Fitzgerald (2000) conducted a review in Carotid body chemotransduction. Acetylcholine (ACh) was evaluated on Fulfillment of criteria required to establish a substance as a synaptic transmitter. Acetylcholine fulfills all eight criteria required to establish it as an essential excitatory synaptic transmitter in carotid body chemotransduction.
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