Key result
Intrathecal fentanyl 12.5 μg added to bupivacaine significantly prolonged the duration of effective analgesia compared to bupivacaine alone (254.56 vs 167.36 minutes) in cesarean section.
Why the study?
The study was conducted to evaluate the efficacy and safety of fentanyl with hyperbaric bupivacaine in spinal anesthesia for caesarean section.
Does the addition of intrathecal fentanyl to bupivacaine improve sensory block and postoperative analgesia in women undergoing elective cesarean section?
RCT (n=50)
Randomly divided
No
Does the addition of intrathecal fentanyl to bupivacaine improve sensory block and postoperative analgesia in women undergoing elective cesarean section?
Absolute Event Rate: 254.56% vs 167.36%
p-value: p=<0.001
The addition of 12.5 μg fentanyl to intrathecal bupivacaine significantly prolongs sensory block and postoperative analgesia without adverse hemodynamic or neonatal effects during cesarean section.
No takes yet. Share an insight, caveat, or question.
Fentanyl adjunct may improve spinal anesthesia for caesarean; leaves open need for randomized confirmation of efficacy and safety.
PRAJAPATI et al. (2022) conducted an RCT in Elective cesarean section (n=50). Bupivacaine with fentanyl vs. 2.0 ml of 0.5% hyperbaric bupivacaine with 0.25 ml normal saline was evaluated on Duration of effective analgesia (p=<0.001). Intrathecal fentanyl 12.5 μg added to bupivacaine significantly prolonged the duration of effective analgesia compared to bupivacaine alone (254.56 vs 167.36 minutes) in cesarean section.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: