What question did this study set out to answer?

Determine the toxic effects of low-dose exposure to six trace elements in drinking water on the reproduction and survival of mice and rats across multiple generations.

August 1, 1971Archives of Environmental Health An International Journal

Toxic Effects of Trace Elements on the Reproduction of Mice and Rats

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Authors

HSHenry A. SchroederDartmouth College MMMarian Mitchener

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Implication

Multi-generation animal study reveals severe reproductive toxicity from low-dose trace elements in mice and rats, highlighting critical risks to mammalian breeding and survival.

Key Points

Determine the toxic effects of low-dose exposure to six trace elements in drinking water on the reproduction and survival of mice and rats across multiple generations.
Maintained breeding mice and rats through three generations in an environment strictly controlled against extraneous metal contamination.
Administered low doses of six trace elements (including selenate, lead, cadmium, molybdate, arsenic, titanium, and nickel) via drinking water, with controls given doubly deionized water.
In mice, selenate (3 ppm) caused excess pre-weaning mortality, runting, and breeding failure, while lead (25 ppm) and cadmium (10 ppm) caused total strain extinction within two generations alongside severe abnormalities.
Molybdate (10 ppm) exhibited mild reproductive toxicity, arsenic altered male-to-female sex ratios, and in rats, lead, titanium, and nickel produced substantial early mortality and runting.

Cite This Study

Schroeder et al. (1971) studied this question.

synapsesocial.com/papers/6a901e0855a9abd3b08403d0 https://doi.org/10.1080/00039896.1971.10665963

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Implication

Multi-generation animal study reveals severe reproductive toxicity from low-dose trace elements in mice and rats, highlighting critical risks to mammalian breeding and survival.

Toxic Effects of Trace Elements on the Reproduction of Mice and Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Toxic Effects of Trace Elements on the Reproduction of Mice and Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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