What question did this study set out to answer?

To determine whether pubertal arsenic exposure exacerbates developmental and reproductive toxicities in male rats previously exposed to lead during the perinatal period.

January 1, 2018Toxicology ResearchOpen Access

Arsenic aggravated reproductive toxicity in male rats exposed to lead during the perinatal period

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Authors

ARA. K. Sai Siva Ram KRK. Pratap Reddy BGB. P. Girish

Discussion

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Overview

Animal study reveals pubertal arsenic exposure exacerbates lead-induced testicular toxicity and fertility impairment in male rats, suggesting synergistic risks from sequential heavy metal exposures.

Key Points

To determine whether pubertal arsenic exposure exacerbates developmental and reproductive toxicities in male rats previously exposed to lead during the perinatal period.
Maternal rats consumed drinking water with or without 819 mg/L lead from conception through weaning, and pup developmental milestones and reflexes were evaluated.
Control and perinatally lead-exposed male offspring received water with or without 2.3 mg/L arsenite from post-natal day 55 to adulthood at post-natal day 115.
Reproductive organ weights, sperm parameters, steroidogenic enzyme activities, oxidative stress markers, and functional mating outcomes were measured.
Perinatal lead exposure significantly delayed cliff avoidance, negative geotaxis, surface righting, wire mesh climbing, and testis descent despite normal litter size and pup survival.
Exposure to lead or arsenic significantly reduced reproductive organ weights, daily sperm production, sperm motility, and 3β- and 17β-hydroxysteroid dehydrogenase activities while increasing reactive oxygen species and lipid peroxidation.
Combined pubertal arsenic and perinatal lead exposure aggravated reproductive and biochemical deficits beyond individual exposures, significantly lengthening conception time and lowering fetal implantation numbers.

Cite This Study

Ram et al. (2018) studied this question.

synapsesocial.com/papers/6a9e2d2d0802d747abf6d2c1 https://doi.org/10.1039/c8tx00146d

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January 1, 2018Toxicology ResearchOpen Access

Arsenic aggravated reproductive toxicity in male rats exposed to lead during the perinatal period

View Full Paper

Ask AI

Bookmark

Authors

ARA. K. Sai Siva Ram KRK. Pratap Reddy BGB. P. Girish

Discussion

Member takes

Overview

Animal study reveals pubertal arsenic exposure exacerbates lead-induced testicular toxicity and fertility impairment in male rats, suggesting synergistic risks from sequential heavy metal exposures.

Key Points

To determine whether pubertal arsenic exposure exacerbates developmental and reproductive toxicities in male rats previously exposed to lead during the perinatal period.
Maternal rats consumed drinking water with or without 819 mg/L lead from conception through weaning, and pup developmental milestones and reflexes were evaluated.
Control and perinatally lead-exposed male offspring received water with or without 2.3 mg/L arsenite from post-natal day 55 to adulthood at post-natal day 115.
Reproductive organ weights, sperm parameters, steroidogenic enzyme activities, oxidative stress markers, and functional mating outcomes were measured.
Perinatal lead exposure significantly delayed cliff avoidance, negative geotaxis, surface righting, wire mesh climbing, and testis descent despite normal litter size and pup survival.
Exposure to lead or arsenic significantly reduced reproductive organ weights, daily sperm production, sperm motility, and 3β- and 17β-hydroxysteroid dehydrogenase activities while increasing reactive oxygen species and lipid peroxidation.
Combined pubertal arsenic and perinatal lead exposure aggravated reproductive and biochemical deficits beyond individual exposures, significantly lengthening conception time and lowering fetal implantation numbers.

Cite This Study

Ram et al. (2018) studied this question.

synapsesocial.com/papers/6a9e2d2d0802d747abf6d2c1 https://doi.org/10.1039/c8tx00146d

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