Key result
Sugammadex use in adult surgical patients with end-stage renal disease resulted in a 2.2% incidence of postoperative tracheal re-intubation within 48 hours, with no recurrence of blockade.
Why the study?
Sugammadex is not recommended for patients with end-stage renal disease due to renal excretion, but reports exist of its use in this population.
Is sugammadex safe and effective for reversing neuromuscular blockade in surgical patients with end-stage renal disease?
Comparison
Sugammadex administration
Design
Two-institutional retrospective observational study
Follow-up
48 h
Authors
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May support sugammadex reversal in ESRD surgery; extends limited data but remains hypothesis-generating pending RCTs.
Observational (n=158)
Yes
Is sugammadex safe and effective for reversing neuromuscular blockade in surgical patients with end-stage renal disease?
Sugammadex appears safe and effective for reversing neuromuscular blockade in patients with end-stage renal disease on renal replacement therapy, despite current recommendations against its use in this population.
Adams et al. (2019) conducted an observational in End-stage renal disease (n=158). Sugammadex was evaluated on Incidence of postoperative tracheal re-intubation within 48 h. Sugammadex use in adult surgical patients with end-stage renal disease resulted in a 2.2% incidence of postoperative tracheal re-intubation within 48 hours, with no recurrence of blockade.
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