Why the study?
Does propofol compared to barbiturates affect QTc interval, heart rate, and arterial pressure during anesthesia induction in children?
Population
123 ASA class I or II children undergoing outpatient otolaryngological surgery, premedicated with oral…
Comparison
Propofol 1.5, 2, or 2.5 mg/kg IV for induction… vs Thiopentone 5 mg/kg or methohexitone 2 mg/kg IV
Design
RCT, Randomly allocated to one of the three propofol groups or to the…
Follow-up
Peri-induction period (up to post-intubation)
Authors
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Propofol warrants caution for induction in children; extends RCT evidence on anesthetic-specific QT and rhythm effects.
Does propofol compared to barbiturates affect QTc interval, heart rate, and arterial pressure during anesthesia induction in children?
Propofol induction in children is associated with QTc prolongation and a higher incidence of bradycardia and junctional rhythm compared to barbiturates.
Saarnivaara et al. (1993) studied this question.