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August 1, 1988Anaesthesia

Comparison between propofol and thiopentone for induction of anaesthesia in children

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Why the study?

Does propofol 2.5 mg/kg improve induction characteristics and safety compared to thiopentone 5 mg/kg in children undergoing elective surgery?

Population

120 children undergoing elective surgery

Comparison

Propofol 2.5 mg/kg vs Thiopentone 5 mg/kg

Design

RCT, randomised, open study

Follow-up

during and after anaesthesia

Authors

MVM. ValtonenTurku University HospitalEIE IisaloTurku University HospitalJKJ KantoUniversity of Vienna

Discussion

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Implication

Propofol may be preferred over thiopentone for pediatric induction due to better intubation stability; extends RCT evidence on hemodynamic trade-offs.

Structured PICO

Does propofol 2.5 mg/kg improve induction characteristics and safety compared to thiopentone 5 mg/kg in children undergoing elective surgery?

P
Population
120 children undergoing elective surgery
I
Intervention
Propofol 2.5 mg/kg
C
Comparator
Thiopentone 5 mg/kg
O
Outcome
Induction characteristics including speed, smoothness, side effects, and haemodynamic responsesafety

Propofol is a safe and effective alternative to thiopentone for anesthesia induction in children, offering better haemodynamic stability during intubation despite more injection discomfort.

Cite This Study

Valtonen et al. (1988) studied this question.

synapsesocial.com/papers/6a87ec7f7d1a7154c5016beehttps://doi.org/10.1111/j.1365-2044.1988.tb04162.x
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