Why the study?
Does propofol 1 mg/kg compared to thiopentone 2 mg/kg improve haemodynamic stability during induction of anaesthesia in elderly high-risk patients?
Does propofol 1 mg/kg compared to thiopentone 2 mg/kg improve haemodynamic stability during induction of anaesthesia in elderly high-risk patients?
Propofol 1 mg/kg can be safely used for induction of anesthesia in elderly high-risk patients without deleterious cardiovascular effects.
Propofol shows comparable haemodynamic stability to thiopentone; leaves open confirmation of safety in randomized trials.
Twenty elderly patients of ASA grade 3 or 4, received either propofol 1 mg/kg or thiopentone 2 mg/kg for induction of anaesthesia. These doses provided a convenient level of anaesthesia for all patients. There were no significant intra- or intergroup haemodynamic changes, with the exception of a decrease in diastolic pressure and rate-pressure product after propofol. It is concluded that propofol 1 mg/kg can be used to induce anaesthesia in elderly high risk patients without deleterious cardiovascular effects.
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Steib et al. (1988) studied this question.
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