May 1, 1986Anaesthesia

Sensitivity to propofol in the elderly

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Why the study?

Does patient age influence the required induction dose and acute toxicity of propofol in fit, unpremedicated patients?

Population

609 fit, unpremedicated patients undergoing induction of anaesthesia

Comparison

Propofol injection vs Patients under 60 years compared to patients…

Design

Cohort

Authors

JDJOHN W. DUNDEEIsfahan University of Medical Sciences JMJ. S. C. McCollumQueen's University Belfast CPCC PattersonQueen's University Belfast

Discussion

Member takes

Implication

Supports age-adjusted propofol dosing in induction; hypothesis-generating and requires randomized confirmation before practice change.

Structured PICO

Does patient age influence the required induction dose and acute toxicity of propofol in fit, unpremedicated patients?

Population

609 fit, unpremedicated patients undergoing induction of anaesthesia

Intervention

Propofol injection (Study 1: 1.25 mg/kg over 20 seconds followed by 10-mg increments every 15 seconds; Study 2: bolus over 20 seconds of 1.5-3.0 mg/kg or 1.25-2.25 mg/kg depending on age)

Comparator

Patients under 60 years compared to patients over 60 years

Outcome

Dose required for induction of anaesthesia (loss of verbal contact)

Elderly patients exhibit marked sensitivity to propofol, requiring lower induction doses and experiencing greater acute toxicity at higher doses.

Cite This Study

DUNDEE et al. (1986) studied this question.

synapsesocial.com/papers/6a84263f356b31aeb3f2f738 https://doi.org/10.1111/j.1365-2044.1986.tb13271.x

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Sensitivity to propofol in the elderly

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sensitivity to propofol in the elderly

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider