Key result
During propofol and alfentanil anesthesia, patient movement in response to skin incision was significantly lower in patients over 45 years of age compared to those under 45 years (p<0.05).
Why the study?
Does age or weight influence the dose requirements and hemodynamic response to propofol and alfentanil anaesthesia in healthy patients?
Observational (n=60)
Does age or weight influence the dose requirements and hemodynamic response to propofol and alfentanil anaesthesia in healthy patients?
Dose requirements of propofol decrease with age, indicating that young and old patients require different dosing strategies for intravenous anaesthesia.
Answers are grounded in this paper and cite their sources.
May support age-adjusted propofol dosing to account for movement differences; leaves open confirmation in randomized trials.
Sixty healthy patients undergoing body surface surgery were anaesthetised with continuous infusions of propofol (200 micrograms/kg/minute) and alfentanil (0.25 microgram/kg/minute). Additional bolus doses of propofol (20 mg) were given if movement occurred. The incidence of patient movement in response to skin incision was significantly less in patients over 45 years of age than in those below 45 years (p less than 0.05). Maintenance dosage of propofol sufficient to abolish movement decreased with increasing age (p less than 0.001). Systolic blood pressure decreased in most patients over the first 10 minutes of anaesthesia and the magnitude of this decrease increased with age (p less than 0.0001). These parameters did not correlate strongly with body weight. Dose requirements of propofol are not the same for patients of all ages and strongly suggest that young and old patients should not be treated as a homogeneous group, either for investigative or clinical purposes.
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Hilton et al. (1986) conducted an observational in Healthy patients undergoing body surface surgery (n=60). Age > 45 years vs. Age < 45 years was evaluated on Patient movement in response to skin incision (p=<0.05). During propofol and alfentanil anesthesia, patient movement in response to skin incision was significantly lower in patients over 45 years of age compared to those under 45 years (p<0.05).
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