March 28, 2022SHILAP Revista de lepidopterologíaOpen Access

The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients

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Why the study?

Established guidelines do not provide propofol induction dose references for patients aged 75 years and over.

Does age reduce the propofol requirement for inducing loss of consciousness in elderly surgical patients?

Population

80 surgical patients ASA physical status I-II across four age categories

Comparison

Propofol induction requirements across age groups: 45-64 vs 65-74 vs 75-84 vs >= 85 years

Design

Observational study

Authors

HYHua YangShanghai University of Political Science and Law HDHuimin DengShanghai Research Center for Acupuncture and Meridians HCHaiyan ChenMinistry of Education of the People's Republic of China

Discussion

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Implication

May support lower propofol induction doses in patients ≥75 years; leaves open randomized confirmation before practice change.

Structured PICO

Does age reduce the propofol requirement for inducing loss of consciousness in elderly surgical patients?

Population

80 surgical patients (39 female, 41 male, American Society of Anesthesiologists physical status score I-II), subdivided into four age groups: 45-64 years (n=20), 65-74 years (n=20), 75-84 years (n=20), and ≥85 years (n=20).

Intervention

Propofol administered at a rate of 0.3 mg/kg/min alone for inducing loss of consciousness.

Comparator

Comparison across different age groups (Group A: 45-64 years used as reference).

Outcome

Propofol requirement for inducing loss of consciousness (defined by loss of both eyelash reflex and verbal response).surrogate

Age is an independent factor that significantly reduces the propofol requirement for inducing loss of consciousness, suggesting induction doses should be further reduced in patients aged 75 years and older.

Cite This Study

Yang et al. (2022) studied this question.

synapsesocial.com/papers/69d56ef175589c71d767d7e9 https://doi.org/10.3389/fphar.2022.739552

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The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Impact of Age on Propofol Requirement for Inducing Loss of Consciousness in Elderly Surgical Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider