Key result
Propofol induction doses exceed typical geriatric requirements in ~65% of older surgical patients.
Why the study?
Advanced age increases susceptibility to acute adverse effects of propofol, prompting an evaluation of propofol induction dosing patterns in older surgical patients.
Population
350,766 patients aged over 65 years receiving propofol for induction and endotracheal intubation
Design
Multicenter retrospective observational study
Authors
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Excessive propofol dosing is common in older surgical patients; leaves open whether adjustment improves outcomes in prospective trials.
Observational (n=350,766)
Yes
In a nationwide sample of older adults, prevalent propofol induction dosing commonly exceeds the published typically required dose range, highlighting a discordance between expected and actual practice.
Schonberger et al. (2021) conducted an observational in Surgical patients requiring general anesthesia and endotracheal intubation (n=350,766). Propofol was evaluated on Percent of patients receiving propofol induction doses above the described typical geriatric range (95% CI 64.6-65.0). In a nationwide sample of surgical patients aged over 65, 64.8% (95% CI 64.6-65.0) received propofol induction doses exceeding the typical geriatric dose requirement.
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