February 1, 1991Anaesthesia and Intensive Care

Lean Tissue Mass is a useful Predictor of Induction dose Requirements for Propofol

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Why the study?

Does dosing propofol based on lean tissue mass normalize induction dose requirements across age and sex?

Population

92 patients aged between 16 and 85 years

Design

Other

Authors

KLKate LeslieScripps Research Institute DCD. P. CrankshawThe University of Melbourne

Discussion

Member takes

Implication

LTM-based propofol dosing may minimize age/sex effects on induction; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does dosing propofol based on lean tissue mass normalize induction dose requirements across age and sex?

Population

92 patients aged between 16 and 85 years

Intervention

Propofol induction dose based on lean tissue mass (LTM)

Outcome

ED50 values for propofol (end-point for loss of consciousness defined as loss of the ability to hold a light object)

Dosing propofol based on lean tissue mass normalizes patient response across age and sex, suggesting that previously observed age-related decreases in dose requirements may be an artifact of dosing by total body mass.

Cite This Study

Leslie et al. (1991) studied this question.

synapsesocial.com/papers/6a95110a397e3dbeede61d6a https://doi.org/10.1177/0310057x9101900110

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Implication

LTM-based propofol dosing may minimize age/sex effects on induction; hypothesis-generating and requires prospective validation before practice change.

Lean Tissue Mass is a useful Predictor of Induction dose Requirements for Propofol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lean Tissue Mass is a useful Predictor of Induction dose Requirements for Propofol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider