Population
Children requiring anaesthesia or sedation
Design
Review
Authors
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Supports higher propofol dosing in children; leaves open need for randomized trials to guide practice.
Propofol is a safe and effective induction agent in pediatric anesthesia, but pharmacokinetic differences in children necessitate higher dosing.
Morton et al. (1992) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: