Key result
Neither continuous infusion of remifentanil (0.25 or 0.5 μg/kg/min) nor bolus injection of fentanyl (3 μg/kg) prolonged the QTc interval during tracheal intubation under propofol anesthesia.
Why the study?
The study was conducted to examine the effects of remifentanil and fentanyl on the prolongation of corrected QT (QTc) interval caused by tracheal intubation.
Does remifentanil compared to fentanyl affect QTc interval prolongation during tracheal intubation with propofol induction?
RCT (n=75)
Randomized
No
Does remifentanil compared to fentanyl affect QTc interval prolongation during tracheal intubation with propofol induction?
Both remifentanil and fentanyl prevent QTc prolongation following tracheal intubation during propofol anesthesia.
Supports QTc safety of these opioids with propofol intubation; leaves open confirmation in larger, higher-risk cohorts.
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Ishizaki et al. (2019) conducted an RCT in Patients undergoing general anesthesia (n=75). Remifentanil vs. Fentanyl 3 μg/kg bolus was evaluated on QTc interval change from baseline to 2 minutes after tracheal intubation (p=<0.05). Neither continuous infusion of remifentanil (0.25 or 0.5 μg/kg/min) nor bolus injection of fentanyl (3 μg/kg) prolonged the QTc interval during tracheal intubation under propofol anesthesia.
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