Why the study?
Does thiamylal compared to propofol affect the QTc interval during anaesthetic induction in patients undergoing lumbar spine surgery?
Does thiamylal compared to propofol affect the QTc interval during anaesthetic induction in patients undergoing lumbar spine surgery?
During anesthetic induction, thiamylal prolongs the QTc interval whereas propofol shortens it.
Supports preferring propofol over thiamylal for induction when QTc risk matters; extends RCT evidence on anesthetic effects on repolarization.
SUMMARY: The aim of this study was to determine the effect of thiamylal and propofol on heart rate-corrected QT (QTc) interval during anaesthetic induction. We studied 50 patients undergoing lumbar spine surgery. Patients were administered 3 microgxkg(-1) fentanyl and were randomly allocated to receive 5 mgxkg(-1) thiamylal or 1.5 mgxkg(-1) propofol as an induction agent. Tracheal intubation was performed after vecuronium administration. Heart rate, mean arterial pressure, bispectral index score, and 12-lead electrocardiogram were recorded at the following time points: just before (T1) and 2 min after (T2) fentanyl administration; 2 min after anaesthetic administration (T3); 2.5 min after vecuronium injection (T4); and 2 min after intubation (T5). Thiamylal prolonged (p < 0.0001), but propofol shortened (p < 0.0001), the QTc interval.
No takes yet. Share an insight, caveat, or question.
Higashijima et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: