Key result
Anesthesia induction with high-dose remifentanil and low-dose midazolam significantly reduced the administration of vasopressors (37% vs 65%, p<0.001) compared to propofol and fentanyl in patients undergoing cardiovascular surgery.
Why the study?
The study was conducted to evaluate the effects of different anesthesia induction methods on hemodynamics during cardiovascular surgery.
Does anesthesia induction with low-dose midazolam and high-dose remifentanil improve hemodynamic stability compared to propofol and fentanyl in patients undergoing cardiovascular surgery?
Observational (n=181)
No
Does anesthesia induction with low-dose midazolam and high-dose remifentanil improve hemodynamic stability compared to propofol and fentanyl in patients undergoing cardiovascular surgery?
Absolute Event Rate: 37% vs 65%
p-value: p=<0.001
Anesthesia induction with low-dose midazolam and high-dose remifentanil is associated with less blood pressure reduction and reduced need for vasopressors compared to propofol and fentanyl in patients undergoing cardiovascular surgery.
May support MR induction to limit hypotension in cardiac surgery; observational data leaves open need for randomized trials.
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Nambara et al. (2020) conducted an observational in Cardiovascular surgery (n=181). Low-dose midazolam and high-dose remifentanil vs. Propofol and fentanyl was evaluated on Administration of vasopressors (p=<0.001). Anesthesia induction with high-dose remifentanil and low-dose midazolam significantly reduced the administration of vasopressors (37% vs 65%, p<0.001) compared to propofol and fentanyl in patients undergoing cardiovascular surgery.
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