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September 5, 2025Journal of Nippon Medical SchoolOpen Access

Comparison of Effects of Remimazolam and Midazolam plus Sevoflurane on Intraoperative Hemodynamics and Opioid Administration: A Retrospective Cohort Study

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Authors

YTYukiko TashiroDHDaisuke HayashiKagoshima UniversityDNDai NamizatoNippon Medical School

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Overview

Retrospective cohort study compares hemodynamics and opioid use in patients undergoing anesthesia, suggesting remimazolam is noninferior to conventional regimens.

Key Points

  • Remimazolam maintained hemodynamics as effectively as midazolam plus sevoflurane during surgery.
  • Maximum rate of remifentanil administration was significantly higher in the remimazolam group, P=0.012.
  • Retrospective cohort study of patients undergoing transcatheter aortic valve implantation analyzed hemodynamics and opioid usage.
  • Findings highlight remimazolam's effectiveness in maintaining stable hemodynamics even with opioid administration.

Cite This Study

Tashiro et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d206d6d5674bcd00f59https://doi.org/10.1272/jnms.jnms.2025_92-403
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Remimazolam vs. Sevoflurane Anesthesia on Intraoperative Hemodynamics in Patients with Gastric Cancer Undergoing Robotic Gastrectomy: A Propensity Score-Matched Analysis2022 · 33 citations
  2. 2Remimazolam for induction of anesthesia in elderly patients with severe aortic stenosis: a prospective, observational pilot study2021 · 82 citations
  3. 3Comparison of the Incidence of Postoperative Acute Kidney Injury Following the Administration of Remimazolam or Sevoflurane in Elderly Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial2023 · 19 citations
  4. 4Etomidate vs propofol in coronary heart disease patients undergoing major noncardiac surgery: A randomized clinical trial2021 · 19 citations
  5. 5Relationship between Intraoperative Hypotension, Defined by Either Reduction from Baseline or Absolute Thresholds, and Acute Kidney and Myocardial Injury after Noncardiac Surgery2016 · 1,136 citations