Why the study?
Do atracurium and vecuronium block nicotine-induced carotid body chemoreceptor responses in a rabbit model?
Population
Carotid body with sinus nerve removed en bloc from thiopentone-anaesthetized adult male New Zealand rabbits
Comparison
30 min perfusion of atracurium or vecuronium… vs Baseline responses to 500 microg nicotine
Design
Preclinical
Authors
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Hypothesis-generating for neuromuscular blocker effects on carotid chemoreflexes; does not support practice changes in humans.
Do atracurium and vecuronium block nicotine-induced carotid body chemoreceptor responses in a rabbit model?
Atracurium and vecuronium in equipotent concentrations block nicotine-induced chemoreceptor responses of the carotid body in a rabbit model.
Kim et al. (2002) studied this question.
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