Key result
Andaliman ethanol extract at 150 or 300 mg/kg reduced doxorubicin-induced hematological toxicity to near-normal levels and decreased lymphocyte and neutrophil suppressive activity.
Why the study?
Doxorubicin has harmful effects on blood hematology, and antioxidant properties of plants may reduce this toxicity. This study aimed to determine the effect of andaliman ethanolic extract on doxorubicin-induced toxicity in rats.
Does Andaliman ethanol extract reduce doxorubicin-induced hematological toxicity in male rats?
Does Andaliman ethanol extract reduce doxorubicin-induced hematological toxicity in male rats?
Andaliman ethanol extract may reduce doxorubicin-induced hematological toxicity in a rat model.
May attenuate doxorubicin hematologic toxicity in rats; leaves open clinical translation.
Introduction: Doxorubicin is one of the chemotherapy drugs that have harmful effects on blood hematology. Blood hematological diseases are caused by its adverse effects and anticancer properties. The antioxidant properties of several plants have been reported to be closely related to reduced toxicity in blood hematology. Andaliman (Zanthoxylum acanthopodium) ethanolic extract (AEE) is thought to reduce the toxicity of doxorubicin due to the antioxidant properties of its secondary metabolite content. This study aimed to determine the effect of AEE on doxorubicin-induced rats and its effect on blood cells. Materials and Method: A total of 24 male rats were divided into 6 groups: (1) Normal group; (2) 0.5% Na-CMC group; (3) 50 mg/kg BW quercetin group; (4) AEE 75 mg/kg BW group; (5) AEE 150 mg/kg BW group; and (6) AEE group 300 mg/kg BW administered orally for 9 days. On days 8 and 9, doxorubicin 10 mg/kg BW was administered. Rats were sacrificed for blood collection, and measured at the Integrated Laboratory of the USU Hospital. Results: AEE reduces the toxicity of doxorubicin on blood parameters. Furthermore, it affects Hb, white blood cells, platelet cells, monocytes, lymphocytes, neutrophils, and several related protein metabolisms as well as organ damage. Dose 150 or 300 mg/kg AEE reduce all blood toxins to near-normal levels and decrease the lymphocyte and neutrophil suppressive activity of doxorubicin. Conclusion: Andaliman ethanol extract can improve Hb count, white blood cells, platelet cells, monocytes, lymphocytes, neutrophils, protein metabolism, and organ damage. Furthermore, AEE can be used in combination with doxorubicin to reduce its hematological toxicity.
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Angela et al. (2023) studied Doxorubicin-induced hematological toxicity (n=24). Andaliman (Zanthoxylum acanthopodium) ethanolic extract vs. Normal group, 0.5% Na-CMC, or 50 mg/kg BW quercetin was evaluated on Blood parameters including Hb, white blood cells, platelets, monocytes, lymphocytes, and neutrophils. Andaliman ethanol extract at 150 or 300 mg/kg reduced doxorubicin-induced hematological toxicity to near-normal levels and decreased lymphocyte and neutrophil suppressive activity.
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