Key result
Doxorubicin administration at 2.5 and 5 mg/kg/week for four weeks induced significant hematological abnormalities and elevated hepatic (P<0.05) and renal markers (P<0.001) in rats.
Why the study?
Doxorubicin is a highly efficacious cancer drug, but its clinical usefulness remains restricted due to specific toxicities.
Does doxorubicin cause hematological and biochemical toxicity in a rat model?
Does doxorubicin cause hematological and biochemical toxicity in a rat model?
p-value: p=<0.05
Doxorubicin administration in a rat model induces significant hematological suppression along with hepatic and renal toxicity.
Doxorubicin induces multi-organ toxicity in rats; leaves open translation to human monitoring and mitigation strategies.
Doxorubicin is an anthracycline drug first extracted from Streptomyces peucetius var. caesius in the 1970’s. It used routinely as highly efficacious drug in many kinds of cancers. But its clinical usefulness is still restricted due to its specific toxicities. This study was designed to investigate doxorubicin-induced toxicity in albino rat model. Thirty male young adult Sprague Dawley rats were divided into Three groups. The first served as control group while second and third group treated with 2.5 and 5mg / kg /week. Two hours post DOX administration rats from all the groups were killed, blood samples were drawn for hematological and biochemical changes. Data were analyzed using (SPSS, verson 22). Hematological parameters obtained from rats treated with Dox revealed that Dox doses induced decrease in RBCs Count, Hemoglobin (Hb) concentration and HCT % when compared with the corresponding values of control rats. Otherwise, WBC.s differential count including (lymphocyte, monocyte, neutrophil, monocyte as well as neutrophil) and platelets count showed a significant decrease (P<0.05) when compared with the values of control rats. DOX doses for four weeks induced hepatic damage as reflected by significantly (p < 0.05) elevated serum ALT, TSB, and ALP enzymes activities when compared to control group. Albumin concentrations recorded a significant decrease. While serum urea concentration and creatinine levels were elevated (P<0.001) as compared with the values of control rats. The present study shed more of the light on the effect of Doxorubicin-induced toxicity in albino rat model. Showing several biochemical and hematological abnormal effects.
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Thabit et al. (2021) studied Doxorubicin-induced toxicity (n=30). Doxorubicin vs. Control group was evaluated on Hematological and biochemical changes (p=<0.05). Doxorubicin administration at 2.5 and 5 mg/kg/week for four weeks induced significant hematological abnormalities and elevated hepatic (P<0.05) and renal markers (P<0.001) in rats.
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