Key result
Doxorubicin administration at 30 mg/kg over 10 weeks significantly increased serum nitrite levels by 101.34% compared to control (115.27 vs 57.25 mg/ml, p<0.001) in albino rats.
Why the study?
Does doxorubicin increase oxidative stress markers in adult albino rats?
Does doxorubicin increase oxidative stress markers in adult albino rats?
Absolute Event Rate: 115.27% vs 57.25%
p-value: p=<0.001
Doxorubicin administration in rats leads to a dose- and time-dependent increase in oxidative stress markers and antioxidant enzymes across multiple organs, including the heart.
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Supports oxidative stress in doxorubicin rat models; hypothesis-generating for human cardiotoxicity, should not change practice.
P et al. (2007) studied Doxorubicin-induced oxidative stress (n=56). Doxorubicin vs. Normal saline was evaluated on Serum nitrite (NO2-) levels at 10 weeks (30 mg/kg dose) (p=<0.001). Doxorubicin administration at 30 mg/kg over 10 weeks significantly increased serum nitrite levels by 101.34% compared to control (115.27 vs 57.25 mg/ml, p<0.001) in albino rats.
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