January 1, 2004Journal of Biochemical and Molecular Toxicology

Nitric oxide and oxidative stress in brain and heart of normal rats treated with doxorubicin: Role of aminoguanidine

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Why the study?

Does aminoguanidine prevent doxorubicin-induced cardiac and cerebral toxicity in male Wistar albino rats?

Population

Male Wistar albino rats (150-200 g)

Comparison

Aminoguanidine injected i.p. at a dose of 100… vs Normal control group and DOX-induced toxicity…

Design

Preclinical

Follow-up

24 h after the last DOX injection (2-week treatment period)

Authors

HEHanan M. Abd Elgawad MEMaha M. El‐SawalhiCairo University

Discussion

Member takes

Implication

Aminoguanidine fails to prevent cardiac enzyme release despite lowering oxidative markers in rats; leaves open whether NO inhibition alone suffices for cardioprotection.

Structured PICO

Does aminoguanidine prevent doxorubicin-induced cardiac and cerebral toxicity in male Wistar albino rats?

Population

Male Wistar albino rats (150-200 g)

Intervention

Aminoguanidine (AG) injected i.p. at a dose of 100 mg/kg 1 h before each doxorubicin (DOX) injection (DOX injected i.p. at 10 mg/kg divided into four equal injections over 2 weeks)

Comparator

Normal control group and DOX-induced toxicity group (DOX alone)

Outcome

Serum lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) activities, and cardiac and cerebral contents of malondialdehyde (MDA), conjugated diene (CD), glutathione (GSH), nitric oxide (NO), cytosolic calcium, superoxide dismutase (SOD), and glutathione peroxidase (GSHP(X))surrogate

Aminoguanidine partially alleviates doxorubicin-induced oxidative stress but fails to prevent cardiac enzyme release, suggesting NO inhibition alone is insufficient for complete cardioprotection.

Cite This Study

Elgawad et al. (2004) studied this question.

synapsesocial.com/papers/6a7d88942d182a3d7e999ddb https://doi.org/10.1002/jbt.20013

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January 1, 2004Journal of Biochemical and Molecular Toxicology

Nitric oxide and oxidative stress in brain and heart of normal rats treated with doxorubicin: Role of aminoguanidine

View Full Paper

Ask AI

Bookmark

Why the study?

Does aminoguanidine prevent doxorubicin-induced cardiac and cerebral toxicity in male Wistar albino rats?

Population

Male Wistar albino rats (150-200 g)

Comparison

Aminoguanidine injected i.p. at a dose of 100… vs Normal control group and DOX-induced toxicity…

Design

Preclinical

Follow-up

24 h after the last DOX injection (2-week treatment period)

Authors

HEHanan M. Abd Elgawad MEMaha M. El‐SawalhiCairo University

Discussion

Member takes

Implication

Aminoguanidine fails to prevent cardiac enzyme release despite lowering oxidative markers in rats; leaves open whether NO inhibition alone suffices for cardioprotection.

Structured PICO

Does aminoguanidine prevent doxorubicin-induced cardiac and cerebral toxicity in male Wistar albino rats?

Population

Male Wistar albino rats (150-200 g)

Intervention

Aminoguanidine (AG) injected i.p. at a dose of 100 mg/kg 1 h before each doxorubicin (DOX) injection (DOX injected i.p. at 10 mg/kg divided into four equal injections over 2 weeks)

Comparator

Normal control group and DOX-induced toxicity group (DOX alone)

Outcome

Aminoguanidine partially alleviates doxorubicin-induced oxidative stress but fails to prevent cardiac enzyme release, suggesting NO inhibition alone is insufficient for complete cardioprotection.

Cite This Study

Elgawad et al. (2004) studied this question.

synapsesocial.com/papers/6a7d88942d182a3d7e999ddb https://doi.org/10.1002/jbt.20013

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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