July 26, 1999Nephron Experimental Nephrology

Gene Regulation of Atrial Natriuretic Peptide A, B, and C Receptors in Rat Glomeruli

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Population

Rat glomeruli (in vivo dehydration model and isolated in vitro)

Comparison

Dehydration; hypertonic solutions and Atrial… vs Control rats; isotonic solution

Design

Preclinical

Follow-up

2 days (for in vivo dehydration)

Authors

KIKazuko ItohIndustrial Technology Center of Okayama Prefecture HNHiroshi NonoguchiNational Sagamihara Hospital NSNaoki ShiraishiKindai University Hospital

Discussion

Member takes

Implication

Dehydration effects on ANP receptors in rats should not guide clinical care; leaves open relevance to human volume regulation or heart failure.

Structured PICO

Population

Rat glomeruli (in vivo dehydration model and isolated in vitro)

Intervention

Dehydration (in vivo); hypertonic solutions (NaCl, mannitol, raffinose, urea) and Atrial natriuretic peptide (ANP) (in vitro)

Comparator

Control rats (in vivo); isotonic solution (in vitro)

Outcome

mRNA expression of ANPR-A, B, and Csurrogate

Dehydration down-regulates ANP receptor mRNA expression in rat glomeruli, likely driven by lower circulating ANP levels rather than increased plasma osmolality.

Cite This Study

Itoh et al. (1999) studied this question.

synapsesocial.com/papers/6a902713c63bb9fb07dd77b9 https://doi.org/10.1159/000020621

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Implication

Dehydration effects on ANP receptors in rats should not guide clinical care; leaves open relevance to human volume regulation or heart failure.

Gene Regulation of Atrial Natriuretic Peptide A, B, and C Receptors in Rat Glomeruli

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Gene Regulation of Atrial Natriuretic Peptide A, B, and C Receptors in Rat Glomeruli

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider