Key result
Aortic stenosis at diagnosis of bicuspid aortic valve strongly predicted the need for future aortic surgery (HR 4.1), alongside ascending aorta dilatation and left ventricular enlargement.
Why the study?
What baseline factors predict the need for surgery in patients with bicuspid aortic valve managed with a conservative approach?
Cohort (n=120)
No
What baseline factors predict the need for surgery in patients with bicuspid aortic valve managed with a conservative approach?
Hazard Ratio: 4.1 (95% CI 1.9–9.3)
p-value: p=0.0001
In patients with bicuspid aortic valve managed conservatively, baseline aortic stenosis, ascending aorta dilatation, and severe left ventricular dilatation strongly predict the need for future surgery.
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May guide risk-stratified surveillance in conservatively managed bicuspid aortic valve; hypothesis-generating until confirmed prospectively.
Alegret et al. (2013) conducted a cohort in Bicuspid Aortic Valve (n=120). Aortic stenosis at diagnosis vs. Absence of aortic stenosis was evaluated on Need for aortic surgery during follow-up (HR 4.1, 95% CI 1.9-9.3, p=0.0001). Aortic stenosis at diagnosis of bicuspid aortic valve strongly predicted the need for future aortic surgery (HR 4.1), alongside ascending aorta dilatation and left ventricular enlargement.
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