Differentiation of Types of Poliomyelitis Viruses

David Bodian

doi:10.1093/oxfordjournals.aje.a119271

March 1, 1949American Journal of Epidemiology

Differentiation of Types of Poliomyelitis Viruses

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Key Points

To determine whether poliomyelitis viruses consist of immunologically distinct types by evaluating whether prior infection confers immunity against homologous versus heterologous virus strains in monkeys.
Inoculated nonhuman primates with specific strains of poliomyelitis virus to establish initial infection and convalescence.
Rechallenged convalescent monkeys with either identical or different poliomyelitis virus strains to monitor for second paralytic attacks.
Demonstrated that convalescent monkeys resist reinfection from the original homologous virus strain but remain susceptible to second paralytic attacks following challenge with heterologous strains.
Established the existence of distinct immunological types of poliomyelitis viruses based on differential reinfection patterns.

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Implication

Experimental challenge study demonstrates distinct poliomyelitis virus types causing reinfection in nonhuman primates, indicating the presence of multiple immunological types.

Abstract

DAVID BODIAN; DIFFERENTIATION OF TYPES OF POLIOMYELITIS VIRUSES: I. REINFECTION EXPERIMENTS IN MONKEYS (SECOND ATTACKS)12, American Journal of Epidemiology, Vol

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David Bodian (1949) studied this question.

synapsesocial.com/papers/6a902ac8f8eca73c40041ccc https://doi.org/10.1093/oxfordjournals.aje.a119271

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Differentiation of Types of Poliomyelitis Viruses

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Differentiation of Types of Poliomyelitis Viruses

Key Points

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Implication

Abstract

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