Key result
Failed spinal anesthesia converted to general anesthesia was associated with increased blood loss, rescue opioid use, and time to ambulation compared to successful spinal anesthesia (P<.001).
Why the study?
Studies preferring spinal anesthesia for total joint arthroplasty may have selection bias because general anesthesia is often used in higher-risk cases, making patients converted to general anesthesia after failed spinal anesthesia an optimal comparator.
Does failed spinal anesthesia with conversion to general anesthesia worsen clinical outcomes compared to successful spinal anesthesia or primary general anesthesia in patients undergoing primary total joint arthroplasty?
Cohort (n=4,483)
No
Does failed spinal anesthesia with conversion to general anesthesia worsen clinical outcomes compared to successful spinal anesthesia or primary general anesthesia in patients undergoing primary total joint arthroplasty?
p-value: p=<.001
Failed spinal anesthesia with conversion to general anesthesia during total joint arthroplasty is associated with inferior outcomes compared to successful spinal anesthesia, emphasizing the importance of initial success.
Failed SA conversion linked to worse TJA outcomes than successful SA but similar to GA; leaves open optimal strategies in observational data.
BACKGROUND: Spinal anesthesia (SA) is the preferred anesthesia modality for total joint arthroplasty (TJA). However, studies establishing SA as preferential may be subject to selection bias given that general anesthesia (GA) is often selectively utilized on more difficult, higher-risk operations. The optimal comparison group, therefore, is the patient converted to GA due to a failed attempt at SA. The purpose of this study was to determine risk factors and outcomes following failed SA with conversion to GA during primary total hip arthroplasty (THA) or total knee arthroplasty (TKA). METHODS: A consecutive cohort of 4,483 patients who underwent primary TJA at our institution was identified (2,004 THA and 2,479 TKA). Of these patients, 3,307 underwent GA (73.8%), 1,056 underwent SA (23.3%), and 130 patients failed SA with conversion to GA (2.90%). Primary outcomes included rescue analgesia requirement in the postanesthesia care unit (PACU), time to ambulation, pain scores in the PACU, estimated blood loss, and 90-day complications. RESULTS: Risk factors for SA failure included older age and a higher comorbidity burden. Failure of SA was associated with increased estimated blood loss, rescue intravenous opioid use, and time to ambulation when compared to the successful SA group in both THA and TKA patients (P < .001). The anesthesia modality was not associated with significant differences in PACU pain scores. The 90-day complication rate was similar between the failed SA and GA groups. There was a higher incidence of postoperative pain prompting unplanned visits and thromboembolism when comparing failed SA to successful SA in both THA and TKA patients (P < .05). CONCLUSIONS: In our series, patients who had failed SA demonstrated inferior outcomes to patients receiving successful SA and similar outcomes to patients receiving GA who did not have an SA attempt. This emphasizes the importance of success in the initial attempt at SA for optimizing outcomes following TJA.
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Chandrashekar et al. (2024) conducted a cohort in Primary total hip or knee arthroplasty (n=4,483). Failed spinal anesthesia with conversion to general anesthesia vs. Successful spinal anesthesia and general anesthesia without spinal attempt was evaluated on Rescue analgesia requirement in the PACU, time to ambulation, PACU pain scores, estimated blood loss, and 90-day complications (p=<.001). Failed spinal anesthesia converted to general anesthesia was associated with increased blood loss, rescue opioid use, and time to ambulation compared to successful spinal anesthesia (P<.001).
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