Why the study?
Does continuation of warfarin without interruption reduce bleeding events compared to heparin bridging in patients undergoing cardiac device procedures?
Population
766 consecutive patients taking long-term warfarin undergoing cardiac device-related procedures.
Comparison
Continuation of warfarin therapy without… vs Discontinued warfarin or discontinued warfarin…
Design
Cohort
Follow-up
30 days
Authors
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Heparin bridging was associated with more bleeding than uninterrupted warfarin; hypothesis-generating and requires randomized confirmation before practice change.
Does continuation of warfarin without interruption reduce bleeding events compared to heparin bridging in patients undergoing cardiac device procedures?
Continuing warfarin with an INR <2.5 during cardiac device procedures is safe and reduces hospital length of stay compared to heparin bridging.
LI et al. (2011) studied this question.
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