Heart Failure Outcome Prediction Using Artificial Intelligence–enabled Coronary Artery Calcium CT Chamber Volumetry Compared to American Heart Association PREVENT and the Agatston Score for Heart Failure Risk Stratification

Eshan Momin; Jaret Barr; Gabby S. Gershon; Brian Zhou; Saikiran Rapaka; Athira Jacob; Ran Xiao; Austin Rim; Carlo N. De Cecco; Marly van Assen

doi:10.1148/ryct.250406

August 1, 2026Radiology Cardiothoracic Imaging

Heart Failure Outcome Prediction Using Artificial Intelligence–enabled Coronary Artery Calcium CT Chamber Volumetry Compared to American Heart Association PREVENT and the Agatston Score for Heart Failure Risk Stratification

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Key result

CAC CT-derived chamber volumes improve HF risk prediction over PREVENT-HF and CAC scores in asymptomatic individuals.

Why the study?

Does Artificial Intelligence-enabled Coronary Artery Calcium CT Chamber Volumetry improve heart failure risk predictions compared to PREVENT-HF and Agatston scores in asymptomatic individuals?

Key Points

To evaluate whether AI-enabled cardiac chamber volumetry from coronary artery calcium CT improves heart failure risk stratification compared to the PREVENT-HF score and Agatston score.
Evaluated artificial intelligence-derived cardiac chamber volumes using coronary artery calcium (CAC) CT scans.
Compared heart failure prediction performance against the American Heart Association PREVENT-HF clinical risk score and standard Agatston scores in asymptomatic individuals.
CAC CT–derived cardiac chamber volumes improved heart failure risk predictions compared to both PREVENT-HF clinical risk and CAC Agatston scores.
The artificial intelligence method successfully identified and characterized cardiac chamber dilatation in asymptomatic individuals.

Structured PICO

Does Artificial Intelligence-enabled Coronary Artery Calcium CT Chamber Volumetry improve heart failure risk predictions compared to PREVENT-HF and Agatston scores in asymptomatic individuals?

P

Population

Asymptomatic individuals

I

Intervention

Artificial Intelligence-enabled Coronary Artery Calcium CT Chamber Volumetry

C

Comparator

American Heart Association PREVENT-HF clinical risk and Agatston CAC scores

O

Outcome

Heart failure risk prediction

Implication

AI-enabled CAC CT chamber volumetry improves heart failure risk prediction beyond standard clinical and CAC scores in asymptomatic individuals.

Abstract

Coronary artery calcium (CAC) CT–derived cardiac chamber volumes improved heart failure risk predictions over the PREVENT-HF clinical risk and CAC scores, enabling reliable chamber dilatation assessment in asymptomatic individuals.

Discussion

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Cite This Study

Momin et al. (2026) studied this question. Coronary artery calcium CT-derived cardiac chamber volumes improved heart failure risk predictions over PREVENT-HF clinical risk and CAC scores in asymptomatic individuals.

synapsesocial.com/papers/6a902f5d36a836210333d7d8 https://doi.org/10.1148/ryct.250406