Towards objective, temporally resolved neurobehavioral predictors of emotional state

Emotion is a core element of human identity and greatly influences our perceptions of the world and our responses to it. Our emotions fluctuate between different states on both long and short timescales and are composed of multiple dissociable elements, including valence (positive vs. negative) and arousal (high vs. low) [1]. Dysregulation of emotional systems is associated with various affective disorders, particularly depression. Over the past 20 years, major depressive disorder (MDD) has been increasingly recognized as a consequence of pathological neurophysiological activity across a distributed network of cortical and subcortical structures, including limbic regions.