Key result
A single 24-hour experience of drinking hypertonic saline robustly reduced salt appetite in adult rats, resulting in a lasting aversion to salty solutions for at least 35 days.
A single 24-hour exposure to hypertonic saline induces a long-lasting aversion to salt in adult rats, associated with persistent changes in hypothalamic gene expression.
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Induces lasting salt aversion after brief exposure in adult rats; extends rodent appetite models but leaves open human translation.
Greenwood et al. (2014) studied Salt appetite. Hypertonic saline (2% w/v NaCl) vs. Water, isotonic saline, dehydration, or 4% high salt diet was evaluated on Salt preference score in two-bottle choice tests (water vs isotonic saline) at 7 and 35 days. A single 24-hour experience of drinking hypertonic saline robustly reduced salt appetite in adult rats, resulting in a lasting aversion to salty solutions for at least 35 days.
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