Population
Chinese hamster ovary (CHO) cells co-expressing KCNQ2/3 potassium channel subunits
Comparison
Retigabine 10 microM vs Absence of retigabine (control recordings)
Design
Preclinical
Authors
Loading...
Retigabine favors KCNQ2/3 opening; extends mechanistic insight but leaves clinical translation open.
Retigabine modifies the steady-state kinetics of KCNQ2/3 potassium channels to favor the open channel configuration.
Tatulian et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: