Key result
Retigabine controls neuronal firing properties primarily through KCNQ3 channels, as deleting these channels greatly diminishes its effect in pyramidal neurons.
Retigabine controls neuronal firing properties primarily through KCNQ3 channels in excitatory neurons.
May inform KCNQ3-selective retigabine analogs; leaves open translation to clinical neurological use.
Retigabine has risen to prominence as a first-in-class potassium channel opener approved by the Food and Drug Administration, with potential for treating multiple neurological disorders. Here, we demonstrate that KCNQ3 channels are the primary target of retigabine in excitatory neurons, as deleting these channels greatly diminishes the effect of retigabine in pyramidal neurons. Our data provide the first indication that retigabine controls neuronal firing properties primarily through KCNQ3 channels.
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Varghese et al. (2021) studied this question. Retigabine was evaluated on Neuronal firing properties. Retigabine controls neuronal firing properties primarily through KCNQ3 channels, as deleting these channels greatly diminishes its effect in pyramidal neurons.
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